Oncolytic adenovirus expressing bispecific antibody targets T‐cell cytotoxicity in cancer biopsies
JD Freedman, J Hagel, EM Scott, I Psallidas… - EMBO molecular …, 2017 - embopress.org
Oncolytic viruses exploit the cancer cell phenotype to complete their lytic life cycle, releasing
progeny virus to infect nearby cells and repeat the process. We modified the oncolytic group
B adenovirus EnAdenotucirev (EnAd) to express a bispecific single‐chain antibody,
secreted from infected tumour cells into the microenvironment. This bispecific T‐cell engager
(Bi TE) binds to Ep CAM on target cells and cross‐links them to CD 3 on T cells, leading to
clustering and activation of both CD 4 and CD 8 T cells. Bi TE transcription can be controlled …
progeny virus to infect nearby cells and repeat the process. We modified the oncolytic group
B adenovirus EnAdenotucirev (EnAd) to express a bispecific single‐chain antibody,
secreted from infected tumour cells into the microenvironment. This bispecific T‐cell engager
(Bi TE) binds to Ep CAM on target cells and cross‐links them to CD 3 on T cells, leading to
clustering and activation of both CD 4 and CD 8 T cells. Bi TE transcription can be controlled …
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